The pharmacokinetics of baclofen have been evaluated by repeated administration of oral baclofen tablets in healthy volunteers. In the same study, the area under the serum concentration-time curve (AUC) and maximum concentration of baclofen were also determined for healthy volunteers. In this study, the pharmacokinetic profile of baclofen was assessed in patients with acute interstitial nephritis and in a group of healthy volunteers. The pharmacokinetic results indicated that the pharmacokinetics of baclofen in patients with acute interstitial nephritis and in a group of healthy volunteers was dose-dependent and that the pharmacokinetics of baclofen in patients with a group of healthy volunteers were dose-dependent.
Citation:Lam J, Kastin A, Svanstad V, Van den Eycken R, et al. (2019) Pharmacokinetic profile of baclofen in healthy volunteers. PLoS ONE 9(6): e028464. https://doi.org/10.1371/journal.pone.028464
Editor:Lam J. K. Chuang, Department of Pediatrics, Royal Prince Alfredo Hospital, Singapore
Received:January 16, 2019;Accepted:August 23, 2019;Published:October 9, 2019
Copyright:© 2019 Lam et al. This is an open-access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding:This work was supported by a grant from the European Research Foundation (FR�F) to J. L. Chuang.
Competing interests:The authors have declared that no competing interests exist.
The pharmacokinetics of baclofen (B) in healthy volunteers has been evaluated using repeated administration of oral baclofen tablets in healthy volunteers. The AUC and Cmax values of baclofen, a drug that has been used for its initial and maintenance treatment of multiple sclerosis, have been reported to be 2.5–3.0 times higher than that of the usual dose of baclofen, which is generally administered in doses up to 4 g daily. In this study, the AUC and Cmax values were determined in healthy volunteers who were treated with oral baclofen tablets, while the results showed that the AUC and Cmax values were higher than that of baclofen in patients with interstitial nephritis. Therefore, the pharmacokinetic profile of baclofen in patients with acute interstitial nephritis and in a group of healthy volunteers is dose-dependent and the pharmacokinetic profiles of baclofen in patients with a group of healthy volunteers are dose-dependent.
Baclofen has been used as an antipyretic and muscle relaxant for the treatment of multiple sclerosis (MS). The AUC and Cmax values of baclofen were 2.5 times higher than that of the usual dose of baclofen, which is generally administered in doses up to 4 g daily in a single dose. However, the AUC values of baclofen in patients with interstitial nephritis and a group of healthy volunteers are dose-dependent. The AUC and Cmax values of baclofen in patients with a group of healthy volunteers were higher than those of the group of patients with interstitial nephritis. Therefore, the AUC and Cmax values of baclofen in patients with a group of healthy volunteers are dose-dependent and the AUC and Cmax values of baclofen in patients with a group of healthy volunteers are dose-dependent. The pharmacokinetic profiles of baclofen in healthy volunteers were also determined.
The AUC and Cmax values of baclofen in healthy volunteers were higher than that in the interstitial nephritis group of patients. Therefore, the AUC and Cmax values were higher than that of baclofen in patients with interstitial nephritis. Therefore, the AUC and Cmax values were higher than that of baclofen in the interstitial nephritis group of patients. The pharmacokinetic profiles of baclofen in patients with a group of healthy volunteers were also determined.
The AUC and Cmax values of baclofen were increased in patients with acute interstitial nephritis and in a group of healthy volunteers.
Aceveda 20 CapsulescontainsBaclofenas aprescription and delivery drug.
Baclofen is amuscle relaxantthatblocks central nervous system activity. Itprevents the spasm in cerebral palsy– a condition affecting the motor, cognitive and social functions. Baclofen is used totreat multiple sclerosisandprevent cerebral palsy
The usual dose of baclofen tablets in multiple sclerosis is one 500 mg dose, followed by10, 20, or 40 mg, takenwhen necessaryBaclofen is usually givenwith or without food
Baclofen may have interactions with some medicines. Inform your doctor about all your prescription medicines, including those currently used by your doctor to treat your spasticity.
Before starting baclofen therapy, inform your doctor about your current medicines, including those that your doctor has recommended. They may need to change your dose.
Baclofen may cause side effects. The most common side effects are:
Rarely, baclofen can cause severe allergic reactions such as swelling of the face, throat, tongue, or spinal cord.
Baclofen may interact with some prescription medicines, including:
Before starting treatment with baclofen, inform your doctor about your current medicines, including those that your doctor has recommended. You may be prescribed baclofen for the treatment of spasticity associated with cerebral palsy.
The active ingredient in each baclofen tablet isBaclofen, a muscle relaxantEach baclofen tablet contains500 mg of baclofen
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Back to shell shockPossible side effects of Baclofen (25mg) 100Side effects are as follows: stomach upset, feeling woozy, feeling lightheaded, feeling sick, feeling tired, feeling sick, tired, slow, tired, weak, unwell or weakens your limbs, loss of balance, muscle weakness, pain, numbness, numbness, or tingling, pain, itching, rashes, or redness, drowsiness, confusion, confusion, trouble concentrating, trouble sleeping, sleep problems, unsteadiness, unsteadiness with unusual movement, sweating, tremors, dizziness, drowsiness, restlessness, dry mouth, fatigue, increased thirst, increased hunger, or an erection.
Headache, dizziness, weakness, and irritability are not usually reported. If any serious side effects occur, talk with your doctor or pharmacist.
Dizziness, headache, nausea, and vomiting are some serious side effects.
Dry mouth, sleepiness, dry mouth, constipation, diarrhea, or dizziness are generally not reported.
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Healthylife. offer: 100 tablets. Prescription only medicine. Pharmacy: Concession code: IK-PH-09.
offers: 100 tablets. Pharmacy: Union Pharmacy. quantity of 6 tablets: 100 tablets.
Baclofen is a medication used to treat muscle spasms caused by cerebral palsy, multiple sclerosis, stroke, and other conditions. It belongs to a class of drugs known as central nervous system depressants.
Baclofen is used to treat muscle spasms due to cerebral palsy, multiple sclerosis, stroke, and other conditions. These drugs work by relaxing muscles, thereby helping the nerves to contract and improve muscle spasms.
Baclofen helps the muscles relax and relieve muscle spasms. It may also help to prevent or reduce the worsening of these spasms. Baclofen helps to block certain chemicals in the body that cause muscle spasms.
Take this medication by mouth as directed by your doctor, usually once or twice daily as directed by your doctor.
The dosage is based on your medical condition and response to treatment. Children's dosage is also based on weight. Do not use in elderly orQT prolongation or QT interval or other medical conditions that could make you more susceptible to this condition.
The most common side effects of this drug include sleepiness, tremors, dizziness, drowsiness, headache, constipation, and weakness. If these effects persist or worsen, tell your doctor or pharmacist promptly.
Baclofen is not addictive. You should not take this medication if you do not have a history of substance abuse or mental disorders. Talk to your doctor if you are also using other medications that could interact with this drug.
Follow the directions on your prescription label. Your doctor may change your dose or suggest an additional medicine.
Do not use in elderly orQT interval prolongation or QT interval or other medical conditions that could make you more susceptible to this condition.
The most common side effects of this medication include sleepiness, tremors, dizziness, headache, constipation, and weakness.
Be sure to talk to your doctor if you have any of these problems.
Get medical help right away if you experience any of the following symptoms:
Be sure to talk to your doctor if you have any of these symptoms.
If you experience these symptoms every time your body breaks a bone, contact your doctor.
Baclofen can increase your risk of developing certain side effects. These side effects may not appear at all in your body. Call your doctor if they persist or do not go away.
Some side effects of this medication may occur at any time during treatment.
Baclofen tablets are prescribed to treat muscle spasms caused by multiple sclerosis (MS) or spinal cord injury (SCI). This medicine may be used in combination with other medicines for treating MS or spinal cord injury.
Baclofen works by helping to relieve spasms caused by multiple sclerosis (MS). This medicine is also used to treat muscle spasms, pain, and stiffness caused by various types of spinal cord injuries.
Baclofen is a prescription-only medicine. It is taken by mouth and is available as a tablet. It is usually taken 30 minutes to an hour before a meal. Baclofen tablets are usually taken once or twice daily with a meal.
Baclofen tablets are used to treat muscle spasms caused by multiple sclerosis (MS). This medicine is also used to treat muscle spasms, pain, and stiffness caused by spinal cord injuries. Baclofen tablets are also used to treat muscle spasms, pain, and stiffness caused by SCI.
Take the tablet with a full glass of water or milk, with or without food, for about 5 to 10 minutes. It can take up to an hour or longer for the medicine to work. If the medicine is taken by mouth, you should swallow the tablet whole with a small glass of water or milk. Do not crush, break, or chew the tablet.
The dosage of baclofen tablets will depend on your medical condition and the severity of your muscle spasms. Your doctor will decide the right dosage based on the severity of your muscle spasms.
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